Sv: Fångtråd del 3
Den medicin som används och studeras i England just för EMS/IR, och som kan medverka till större viktnedgång samt lägre insulinnivåer än utan medicin, om den ges i 3 - 6 mån. Syntetiskt sköldkörtelhormon.
Valda delar, full text finns i länken nedan:
Treatment of obesity and insulin resistance with levothyroxine sodium
Most horses or ponies with EMS can be effectively managed by controlling the
diet, instituting an exercise program, and limiting or eliminating access to pasture. However, there are times when these strategies will not improve the situation fast enough to prevent additional episodes of laminitis. In these situations, drug therapy is warranted to lower the likelihood of subsequent laminitis episodes and permanent damage to the feet. If this is the case, talk to your veterinarian about treating your horse with levothyroxine sodium at a high dosage to accelerate weight loss and improve insulin sensitivity. This
drug should only be administered under the direction of a veterinarian and the high dosage should only be used for 3 to 6 months.
---
We have performed three research studies to evaluate the use of levothyroxine sodium (Thyro L®, VetAMix, Division of Lloyd, Inc., Shenandoah, Iowa) in horses.
In our first study, we administered levothyroxine to eight mares according to an incrementally increasing dosing regimen over an 8week period. Mean body weight decreased and insulin sensitivity increased in treated mares.
--
Our second study evaluated the longterm effects of the drug on body weight and insulin sensitivity in six mares over a 12month period.
--
Advanced glucoseinsulin tolerance tests were also performed at 0, 4, 8, and 12 months. Mean (± standard deviation) weight loss was 49 ± 14 kg, 43 ± 7 kg, and 25 ± 18 kg at 4, 8, and 12 months, respectively. This alteration was mirrored by a > 2fold increase in mean insulin sensitivity. No adverse health effects were detected.
--
In our final study, we are examining the effects of levothyroxine on body weight and insulin sensitivity in horses affected by EMS, and this study is ongoing. Preliminary results indicate that EMS treated with levothyroxine sodium (Thyro L®, VetAMix, Division of Lloyd, Inc., Shenandoah, Iowa) lose more weight and show a greater reduction in neck circumference. Horses (n = 4) on a controlled diet exhibited a 5 cm decrease in mean neck circumference over 6 months, whereas the same measurement
decreased by 10 cm in treated horses (n = 4). We have also observed that the cresty neck becomes softer in treated horses and this finding precedes the reduction in neck circumference.
--
Conclusions
Obesity and insulin resistance are important predisposing factors for laminitis in horses and ponies. Diet changes and exercise are key components of any management plan for horses with EMS, and restricted access to pasture is the key to success when trying to induce weight loss.
Levothyroxine sodium (Thyro L®, VetAMix, Division of Lloyd, Inc., Shenandoah, Iowa) can be used to accelerate weight loss and improve insulin
sensitivity when the horse is threatened by laminitis. Weight loss occurs more rapidly when horses are placed on a controlled diet throughout the period of time that levothyroxine sodium is being administered.
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http://www.lloydinc.com/pdfs/N_FrankEquineMetabolicSyndrome.pdf
Medicinerar med vad?
Enligt Strömsholm är nedbantning o motion den enda "medicinen".
Den medicin som används och studeras i England just för EMS/IR, och som kan medverka till större viktnedgång samt lägre insulinnivåer än utan medicin, om den ges i 3 - 6 mån. Syntetiskt sköldkörtelhormon.
Valda delar, full text finns i länken nedan:
Treatment of obesity and insulin resistance with levothyroxine sodium
Most horses or ponies with EMS can be effectively managed by controlling the
diet, instituting an exercise program, and limiting or eliminating access to pasture. However, there are times when these strategies will not improve the situation fast enough to prevent additional episodes of laminitis. In these situations, drug therapy is warranted to lower the likelihood of subsequent laminitis episodes and permanent damage to the feet. If this is the case, talk to your veterinarian about treating your horse with levothyroxine sodium at a high dosage to accelerate weight loss and improve insulin sensitivity. This
drug should only be administered under the direction of a veterinarian and the high dosage should only be used for 3 to 6 months.
---
We have performed three research studies to evaluate the use of levothyroxine sodium (Thyro L®, VetAMix, Division of Lloyd, Inc., Shenandoah, Iowa) in horses.
In our first study, we administered levothyroxine to eight mares according to an incrementally increasing dosing regimen over an 8week period. Mean body weight decreased and insulin sensitivity increased in treated mares.
--
Our second study evaluated the longterm effects of the drug on body weight and insulin sensitivity in six mares over a 12month period.
--
Advanced glucoseinsulin tolerance tests were also performed at 0, 4, 8, and 12 months. Mean (± standard deviation) weight loss was 49 ± 14 kg, 43 ± 7 kg, and 25 ± 18 kg at 4, 8, and 12 months, respectively. This alteration was mirrored by a > 2fold increase in mean insulin sensitivity. No adverse health effects were detected.
--
In our final study, we are examining the effects of levothyroxine on body weight and insulin sensitivity in horses affected by EMS, and this study is ongoing. Preliminary results indicate that EMS treated with levothyroxine sodium (Thyro L®, VetAMix, Division of Lloyd, Inc., Shenandoah, Iowa) lose more weight and show a greater reduction in neck circumference. Horses (n = 4) on a controlled diet exhibited a 5 cm decrease in mean neck circumference over 6 months, whereas the same measurement
decreased by 10 cm in treated horses (n = 4). We have also observed that the cresty neck becomes softer in treated horses and this finding precedes the reduction in neck circumference.
--
Conclusions
Obesity and insulin resistance are important predisposing factors for laminitis in horses and ponies. Diet changes and exercise are key components of any management plan for horses with EMS, and restricted access to pasture is the key to success when trying to induce weight loss.
Levothyroxine sodium (Thyro L®, VetAMix, Division of Lloyd, Inc., Shenandoah, Iowa) can be used to accelerate weight loss and improve insulin
sensitivity when the horse is threatened by laminitis. Weight loss occurs more rapidly when horses are placed on a controlled diet throughout the period of time that levothyroxine sodium is being administered.
---
http://www.lloydinc.com/pdfs/N_FrankEquineMetabolicSyndrome.pdf