Sv: collieägare, se hit!
Det är väl ivermectin de är känsliga mot? Både collie och border men inte bearded.
Problemet är en defekt som kallas MDR1, Multi Drug Resistance.
Raserna som har detta är
* Collie
* Shetland Sheepdog
* Australian Shepherds
* Miniature Australian Shepherds
* Old English Sheepdogs
* English Shephard
* mcNabb
* White Shephard (recently discovered)
* Long-haired Whippets,
* Silken Windhounds
Det är MYCKET mer än Ivomec dom inte tål.
Den kända listan så här långt (som lär utökas vartefter forskarna finner nya rön) är
(knycker detta från min egen hemsida)
Drugs that have been documented to cause problems in dogs with the MDR1 mutation include:
* Ivermectin (antiparasitic agent)-While the dose of ivermectin used to prevent heartworm infection is SAFE in dogs with the mutation (6 micrograms per kilogram), higher doses, such as those used for treating mange (300-600 micrograms per kilogram) will cause neurological toxicity in dogs that are homozygous for the MDR1 mutation (mutant/mutant) and can cause toxicity in dogs that are heterozygous for the mutation (mutant/normal).
* Selamectin, milbemycin, and moxidectin (antaparasitic agents)-Similar to ivermectin, these drugs are safe in dogs with the mutation if used for heartworm prevention at the manufacturer’s recommended dose. Higher doses (generally 10-20 times higher than the heartworm prevention dose) have been documented to cause neurological toxicity in dogs with the MDR1 mutation.
* Loperamide (ImodiumTM; antidiarrheal agent)-At doses used to treat diarrhea, this drug will cause neurological toxicity in dogs with the MDR1 mutation.This drug should be avoided in all dogs with the MDR1 mutation.
* Acepromazine (tranquilizer and pre-anesthetic agent)-In dogs with the MDR1 mutation, acepromazine tends to cause more profound and prolonged sedation.We recommend reducing the dose by 25% in dogs heterozygous for the MDR1 mutation (mutant/normal) and by 30-50% in dogs homozygous for the MDR1 mutation (mutant/mutant).
* Butorphanol (analgesic and pre-anesthetic agent)-Similar to acepromazine, butorphanol tends to cause more profound and prolonged sedation in dogs with the MDR1 mutation.We recommend reducing the dose by 25% in dogs heterozygous for the MDR1 mutation (mutant/normal) and by 30-50% in dogs homozygous for the MDR1 mutation (mutant/mutant).
* Vincristine, Vinblastine, Doxorubicin (chemotherapy agents)-Based on some published and ongoing research, it appears that dogs with the MDR1 mutation are more sensitive to these drugs with regard to their likelihood of having an adverse drug reaction. Bone marrow suppression (decreased blood cell counts, particulary neutrophils) and GI toxicity (anorexia, vomiting, diarrhea) are more likely to occur at normal doses in dogs with the MDR1 mutation. To reduce the likelihood of severe toxicity in these dogs (mutant/normal or mutant/mutant), we recommend reducing the dose by 25-30% and carefully monitoring these patients.
* Read more at the State University of Washington That page also talks about products that appear to be safe, and drugs to keep an eye on, although no reports of problems with MDR1 dogs have been reported yet
Another list of drugs that have been documented, or are strongly suspected to cause problems in dogs with MDR1 mutation:
- Acepromazine (tranquilizer):
- Butorphanol (pain control);
- Cyclosporin (immunosuppression drug);
- Digoxin (heart drug);
- Doxorubicin (anticancer drug);
- Ivermectin (antiparasitic drug);
- Loperamide (Imodium®, antidiarrheal drug);
- Moxidectin;
- Vinblastine (anticancer drug);
- Vincristine (anticancer drug).
Biochemical studies have shown that mutant MDR1 gene has the potential to act on over 50 different drugs. The following drugs may potentially cause problems when given to dogs that have the mutation:
- Domperidone;
- Etoposide;
- Mitoxantrone;
- Morphine;
- Ondansetron;
- Paclitaxel;
- Quinidine;
- Rifampicin.
I Europa är det snabbaste och billigaste labbet för att testa om hunden har MDR1 det här
http://www.laboklin.co.uk/laboklin/showGeneticTest.jsp?testID=8032