G
gustav
min häst har fått denna prognosen av vetrinären. vet inte mycke om det. vet bara att det har med hormonerna att göra.e de någon som har någon erfarnhet om det så berätta gärna\ tack
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Hjärnan producera cortisol?Rumpnissen skrev:Cushing´s syndrom är en sjukdom där hjärnan producerar för mycket kortisol. I mitt stora projektarbete om fång så hade jag med en del om detta då ungefär hälften av alla hästar som drabbats av fång har Cushings. Överskottet av kortisol stör hornproduktionen och det kan vara en (bidragande) orsak till fång.
peter_lundin skrev:Oftast ja, problemet är att det inte finns en viss blodbild som säker ger diagnosen cushing.
ACTH i sig är inte särskilt säkert, överlappet mellan friska o sjuka hästar är för stort.
Vid dex supr skall man helsta ta en rad prov.
För några år sen ringde jag runt en massa för att kolla säkraste sättet att snabbt ställa en diagnos o fick egentligen inget vettigt svar.
PL
"Development of a safe and accurate test for the diagnosis of equine Cushing's disease (01-09)
(funds provided by the Center for Equine Health and the American Horse Shows Association)
Johanna L. Watson
Miriam L. Horowitz
Larry A. Neal
Description of the Problem:
Equine Cushing's disease is caused by a change in the regulation and secretion of hormones from the pituitary gland and is common in older horses and ponies. It can also affect horses as early as ten years of age while they are still reproductively or competitively productive. Cushing's disease can cause serious complications to an animal's quality of life. Only one diagnostic test, the dexamethasone suppression test, has been definitively shown to identify horses with equine Cushing's disease. This test requires the administration of dexamethasone to the horse, which sometimes causes negative side effects including laminitis. A new test for diagnosing this disease is needed in situations where the dexamethasone test cannot be used safely.
Study Objectives:
• Measure two major pituitary hormones as an endocrine profile to provide a safer test for equine Cushing's disease.
Experimental Approach:
Control horses and horses affected with equine Cushing's disease were identified and assigned to groups based on their response to the dexamethasone suppression test. Researchers used commercially available radioimmunoassay kits to measure two major products and one minor product of the pars intermedia (part of the pituitary gland). The resulting values for normal horses were compared with values from horses with Cushing's disease.
Accomplishments/Results:
• Determined that horses with Cushing's disease had significantly higher blood levels of all three pituitary products ( -MSH, -endorphin, ACTH) than normal horses.
• Found that these differences were sufficient in magnitude to distinguish between normal and Cushing's-affected horses with a moderately high degree of certainty.
• Concluded from the results that any of the peptides measured may be used as an alternative diagnostic test in situations in which the dexamethasone suppression test is considered dangerous. "